Related Experiment Video
Updated: May 6, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
Published on: July 14, 2017
CXCR4 in epidermal keratinocytes: crosstalk within the skin
Wendy B Bollag1, William D Hill2
1Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA; Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Medicine (Dermatology), Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA.
Abstract:
In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.
Related Concept Videos
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Renewal of Skin Epidermal Stem Cells
Clinical Applications of Epidermal Stem Cells
Anchoring Junctions
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Cytoskeletal Coordination in Cell Migration

