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Published on: August 11, 2023
Internal carotid artery occlusion: its natural history including recanalization and subsequent neurological events
G Morris-Stiff1, M Teli, P Y Khan
11Department of Surgery, Royal Glamorgan Hospital, Llantrisant, United Kingdom.
Insights
Recanalization of internal carotid artery (ICA) occlusion is common, occurring in 10.3% of patients. This condition is linked to significant neurological events, underscoring the need for duplex ultrasound follow-up.
Area of Science:
- Vascular Neurology
- Cerebrovascular Disease
- Diagnostic Imaging
Background:
- Internal carotid artery (ICA) occlusion poses a risk for cerebrovascular events.
- Understanding the natural history of ICA occlusion, including recanalization, is crucial for patient management.
- Duplex ultrasound is a key diagnostic tool in assessing carotid artery disease.
Purpose of the Study:
- To determine the incidence of recanalization in patients with internal carotid artery (ICA) occlusion.
- To establish the natural history and clinical significance of ICA occlusion recanalization.
- To evaluate the role of duplex ultrasound in monitoring ICA occlusions.
Main Methods:
- Retrospective identification of 153 patients with duplex-confirmed ICA occlusions.
- Follow-up scanning offered to a subgroup of patients.
- Recording of antemortem condition and cause of death for deceased patients.
Main Results:
- Recanalization occurred in 10.3% (8/77) of patients with ICA occlusion, with a median time of 53 months.
- Seven of eight recanalized cases were confirmed by carotid endarterectomy.
- 29% of patients experienced further neurological events, and 23% of deaths were attributed to cerebrovascular accidents in the occluded ICA territory.
Conclusions:
- Recanalization of internal carotid artery occlusion is a notable finding.
- Recanalization is associated with significant neurological events.
- Regular duplex ultrasound follow-up is essential for patients with ICA occlusion.
Objective:
To determine the incidence of recanalization of the occluded internal carotid artery (ICA) and establish its natural history.
Methods:
Patients with duplex-confirmed ICA occlusions were identified, and a subgroup offered repeat scanning. The antemortem condition and cause of death of patients who died were recorded.
Results:
Of 153 patients identified, 77 underwent follow-up at a median of 35 months (interquartile range [IQR]: 14-61).In all, 8 (10.3%) demonstrated recanalization at a median of 53 months (IQR: 35-114). Of 8, 7 underwent carotid endarterectomy with histopathological confirmation of recanalization. Of the 153 patients, 45 (29%) had further neurological events, and 38 (25%) were within the territory of the occluded ICA. In all, 76 patients died, and of the 53 with a confirmed cause of death, 12 (23%) were attributed to a cerebrovascular accident corresponding to the territory of the occluded artery.
Conclusion:
Recanalization of ICA occlusion is common and leads to significant neurological events. Duplex ultrasound follow-up appears mandatory.
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