The 11q23.3 genomic region-rs964184-is associated with cardiovascular disease in patients with rheumatoid arthritis

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R López-Mejías1, F Genre, M García-Bermúdez

  • 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.

Tissue Antigens
|October 18, 2013
PubMed

Insights

The rs964184 genetic polymorphism increases cardiovascular event risk in rheumatoid arthritis (RA) patients. This finding highlights a potential genetic marker for cardiovascular disease in individuals with RA.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Genetics

Background:

  • Rheumatoid arthritis (RA) is an inflammatory condition linked to a higher risk of cardiovascular (CV) events.
  • The rs964184 polymorphism has previously been associated with coronary artery disease in nonrheumatic populations.

Purpose of the Study:

  • To investigate the association between the rs964184 polymorphism and cardiovascular disease risk in Spanish rheumatoid arthritis patients.

Main Methods:

  • Genotyping of 2160 Spanish RA patients for the rs964184 polymorphism.
  • Statistical analysis adjusted for sex, age at diagnosis, and traditional CV risk factors (diabetes mellitus, dyslipidemia, smoking).

Main Results:

  • RA patients with the rs964184 GG genotype showed a significantly higher risk of CV events compared to those with the CC genotype (HR=2.91, P=0.006).
  • Traditional CV risk factors and patient demographics were also associated with increased CV event risk.

Conclusions:

  • The rs964184 polymorphism is significantly associated with cardiovascular disease in rheumatoid arthritis patients.
  • This genetic variant may serve as a predictive biomarker for cardiovascular risk in RA.

Keywords:
11q23.3atherosclerosiscardiovascular diseaserheumatoid arthritisrs964184

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