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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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Published on: October 7, 2016

Thixotropic hydrogelators based on a cyclo(dipeptide) derivative.

Hiroko Hoshizawa¹, Yuta Minemura, Katsunori Yoshikawa

¹Interdisciplinary Graduate School of Science and Technology and ‡Faculty of Textile Science and Technology, Shinshu University , 3-15-1 Tokida, Ueda-shi, Nagano 386-8567, Japan.

Langmuir : the ACS Journal of Surfaces and Colloids

|October 18, 2013

Summary

New thixotropic hydrogelators show reversible gel-sol-gel transitions in various solvents. These self-assembling fibers, driven by hydrogen bonding and van der Waals forces, offer potential for biomedical applications.

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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Published on: October 29, 2013

Area of Science:

Materials Science
Supramolecular Chemistry
Biomaterials

Background:

Thixotropic hydrogelators are crucial for advanced biomedical and biotechnological applications.
Understanding gel-sol-gel transitions is key to developing novel hydrogel materials.

Purpose of the Study:

To synthesize and characterize novel thixotropic hydrogelators.
To investigate the gel-sol-gel transition behavior of these new compounds.
To explore their self-assembly mechanisms and potential applications.

Main Methods:

Synthesis of cyclo(L-O-hydroxyhexylaspartyl-L-phenylalanyl) using 1,6-hexanediol.
Gelation studies in various solvents (water, saline, alcohols, salt solutions).
Transmission Electron Microscopy (TEM) for fiber morphology.
Fourier-Transform Infrared Spectroscopy (FT-IR) for interaction analysis.

Main Results:

The synthesized hydrogelator formed thermally/isothermally reversible physical gels.
Self-assembly into fibers (10-100 nm diameter) observed via TEM.
FT-IR confirmed hydrogen bonding and van der Waals forces as primary interactions.
Thixotropic behavior attributed to disruption of van der Waals forces under shear.

Conclusions:

The novel hydrogelator exhibits robust reversible gelation properties.
The self-assembly and thixotropic behavior are well-defined and reproducible.
These findings highlight the potential of this hydrogelator in biomedical fields.