Related Experiment Video
Updated: May 6, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Clinical and microbiological profile of infectious keratitis in children
Patricia Chirinos-Saldaña, Victor Manuel Bautista de Lucio, Julio Cesar Hernandez-Camarena
1Cornea and Refractive Surgery Department, Institute of Ophthalmology "Fundación de Asistencia Privada Conde de Valenciana", Mexico City, Mexico. labauh@hotmail.com.
Insights
Prompt diagnosis and treatment of infectious keratitis in children are crucial. Ocular trauma and Gram-positive bacteria, particularly Staphylococcus epidermidis, are significant risk factors associated with poor visual outcomes.
Area of Science:
- Ophthalmology
- Microbiology
- Pediatrics
Background:
- Infectious keratitis poses a significant threat to children's vision.
- Understanding its clinical and microbiological aspects is vital for effective management.
Purpose of the Study:
- To delineate the clinical presentation, risk factors, and microbiological landscape of infectious keratitis in pediatric patients.
- To analyze visual and surgical outcomes in children diagnosed with microbial keratitis.
Main Methods:
- Retrospective analysis of medical records for pediatric patients (<16 years) with microbial keratitis.
- Evaluation of clinical data, predisposing factors, microbiological results, and patient outcomes.
Main Results:
- A total of 41 pediatric cases were analyzed, with a mean age of 8.7 years.
- Ocular trauma was the most frequent predisposing factor (25%), identified in 78% of cases.
- Gram-positive bacteria, predominantly Staphylococcus epidermidis, were found in 78.5% of positive cultures.
Conclusions:
- Early diagnosis and intervention are critical for managing infectious corneal ulcers in children.
- Ocular trauma and contact lens use are primary risk factors.
- Gram-positive bacteria are the leading cause, and visual prognosis is often poor.
Background:
Infectious keratitis is a sight-threatening condition for children. The purpose of this study was to describe the clinical profile, risk factors and microbiological profile of infectious keratitis in children.
Methods:
Retrospective review of clinical records of patients under 16 years of age with history of microbial keratitis seen at a tertiary referral center. Clinical characteristics, risk factors, visual and surgical outcomes as well as the microbiological profile are analyzed.
Results:
Forty-one eyes of 41 patients. Mean age was 8.7 years. Time between the onset of symptoms and ophthalmological examination was 12.7 days. Predisposing factors were found in 78%; ocular trauma was the most common (25%). Visual acuity equal or worse than 20/200 at admission correlated positively with a poorer visual outcome, p=0.002. Positivity of cultures was 34%. Gram-positive bacteria were isolated in 78.5%; Staphylococcus epidermidis (28.6%) was the most common microorganism.
Conclusions:
Our study emphasizes the importance of a prompt diagnosis and treatment of infectious corneal ulcers in children. Trauma and contact lenses were the main predisposing factors. Gram-positive organisms were isolated in the vast majority of cases and visual outcomes are usually poor.
Related Concept Videos
Microbiome of the Eye
Viral Meningitis

