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Updated: Feb 12, 2026
06:53
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
9.2K
Going with the flow: from circulating tumor cells to DNA
Francois-Clement Bidard1, Britta Weigelt, Jorge S Reis-Filho
1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Science Translational Medicine
|October 18, 2013
Summary
Liquid biopsies using circulating tumor DNA (ctDNA) offer minimally invasive cancer biomarkers. This review discusses ctDNA
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Circulating tumor DNA (ctDNA) analysis in plasma shows promise for non-invasive cancer diagnostics.
- Previous experience translating circulating tumor cell (CTC) detection into clinical applications informs this work.
Purpose of the Study:
- To discuss the potential of ctDNA as a source of tumor material for biomarker development.
- To highlight the advantages of ctDNA analysis for minimally invasive cancer monitoring.
Main Methods:
- Review of existing literature on ctDNA analysis.
- Drawing parallels with the clinical translation of circulating tumor cell technologies.
Main Results:
- ctDNA analysis represents a viable approach for developing minimally invasive cancer biomarkers.
- The field benefits from lessons learned in the clinical implementation of related liquid biopsy technologies.
Conclusions:
- ctDNA holds significant potential for advancing cancer diagnostics and disease monitoring.
- Further development and validation of ctDNA-based biomarkers are crucial for clinical integration.
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