Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.8K
Whole Body Regeneration01:33

Whole Body Regeneration

3.6K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.6K
Bones of the Upper Limb: Radius01:09

Bones of the Upper Limb: Radius

9.1K
The radius is longer of the two bones that make up the human antebrachium or forearm. At the proximal end, the radius articulates with the capitulum of the humerus and the radial notch of the ulna to form the elbow joint. At the distal end, the radius articulates with the ulna via the ulnar notch, forming the distal radioulnar joint. Distally, the radius also attaches to the carpal wrist bones (scaphoid and lunate) to form the radiocarpal joint.
The radius has a nail-shaped head, and a...
9.1K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.6K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrolytic and enzymatic degradation of linear segmented polyurethane block copolymers studied by ToF-SIMS and atomic force microscopy.

Biointerphases·2025
Same author

Carboxybetaine zwitterionic coatings on kidney dialyzer components: Surface characterization and blood interactions.

Acta biomaterialia·2025
Same author

Allan S. Hoffman's leadership in drug delivery: A historical perspective.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Synthetic vascular graft that heals and regenerates.

Biomaterials·2025
Same author

The Origins of Engineered Biomaterials: NSF-Funded, University of Washington Engineered Biomaterials (UWEB).

Bioengineering (Basel, Switzerland)·2024
Same author

An Innovation Ecosystem: The Center for Dialysis Innovation (CDI).

Journal of the American Society of Nephrology : JASN·2024

Related Experiment Video

Updated: May 6, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
10:36

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

1.0K

Going out on a limb about regrowing an arm.

Buddy D Ratner1

  • 1Departments of Bioengineering and Chemical Engineering, University of Washington Engineered Biomaterials (UWEB21), University of Washington, Seattle, WA, 98195, USA, ratner@uweb.engr.washington.edu.

Journal of Materials Science. Materials in Medicine
|October 18, 2013
PubMed
Summary

Human limb regeneration is possible by harnessing discoveries in cell plasticity and regenerative phenotypes. Recent scientific advances suggest that mature cells and specific immune cells could be key to developing new limb regrowth technologies.

More Related Videos

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

783
Surface Electromyographic Biofeedback as a Rehabilitation Tool for Patients with Global Brachial Plexus Injury Receiving Bionic Reconstruction
09:14

Surface Electromyographic Biofeedback as a Rehabilitation Tool for Patients with Global Brachial Plexus Injury Receiving Bionic Reconstruction

Published on: September 28, 2019

14.3K

Related Experiment Videos

Last Updated: May 6, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
10:36

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach

Published on: May 23, 2025

1.0K
Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
08:11

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation

Published on: June 13, 2025

783
Surface Electromyographic Biofeedback as a Rehabilitation Tool for Patients with Global Brachial Plexus Injury Receiving Bionic Reconstruction
09:14

Surface Electromyographic Biofeedback as a Rehabilitation Tool for Patients with Global Brachial Plexus Injury Receiving Bionic Reconstruction

Published on: September 28, 2019

14.3K

Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Tissue Engineering

Background:

  • Fetuses exhibit scarless wound healing and limb development.
  • Children under two can partially regrow digits.
  • Amphibians possess remarkable limb regeneration capabilities.

Purpose of the Study:

  • To explore the potential for adult human limb regeneration.
  • To review the biological processes involved in amphibian limb regrowth.
  • To identify recent scientific discoveries applicable to human limb regeneration technology.

Main Methods:

  • Review of amphibian limb regeneration mechanisms.
  • Analysis of key factors: innervation, cell memory, signaling, gene regulation, and inflammation.
  • Examination of recent discoveries in cell plasticity and macrophage regenerative potential.

Main Results:

  • Limb regeneration involves specific stages: vasoconstriction, apical epithelial cap formation, fibroblast migration and blastema formation, and blastema coordination.
  • Factors like cell signaling, gene regulation, and inflammatory cells are crucial.
  • Mature cells exhibit plasticity, and macrophages can adopt stem-like, regenerative phenotypes.

Conclusions:

  • Scientific discoveries have provided a foundation for limb regeneration.
  • Mature cell plasticity and reprogrammed macrophages offer promising avenues.
  • The focus should now shift to developing technologies to exploit these findings for human limb regrowth.