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Who's really in control: microbial regulation of protein trafficking in the epithelium

Matthew R Hendricks1, Jennifer M Bomberger

  • 1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

American Journal of Physiology. Cell Physiology
|October 18, 2013
PubMed

Insights

Pathogens disrupt host cell functions to cause disease. Studying these interactions reveals insights into cellular physiology and host-pathogen dynamics.

Area of Science:

  • Microbiology and Cell Biology
  • Host-Pathogen Interactions

Background:

  • Complex evolutionary pressures drive interactions between pathogens and eukaryotic host cells.
  • Pathogens have evolved sophisticated mechanisms to evade host defenses, colonize tissues, and establish replication niches.
  • Understanding these host-pathogen interactions is crucial for deciphering disease mechanisms.

Purpose of the Study:

  • To review how pathogens disrupt host cellular physiology and protein trafficking.
  • To highlight how pathogen-modulated cellular processes inform our understanding of eukaryotic cell biology.
  • To underscore the utility of pathogens as tools for studying cell physiology.

Main Methods:

  • Review of existing literature on host-pathogen interactions.
  • Analysis of specific examples of pathogen-induced disruption of cellular processes.
  • Focus on mechanisms affecting epithelial cell barriers and protein trafficking.

Main Results:

  • Pathogens employ diverse strategies to modulate host cell functions, including disruption of normal physiology.
  • Specific examples illustrate how pathogens interfere with protein trafficking at epithelial barriers.
  • Pathogen-mediated manipulation of cellular processes provides insights into fundamental cell biology.

Conclusions:

  • Pathogens are valuable tools for dissecting eukaryotic cellular physiology.
  • Understanding pathogen strategies enhances knowledge of disease pathogenesis.
  • Investigating host-pathogen interfaces offers a dual benefit to microbiology and cell biology.
Keywords:
endocytosisepitheliumexocytosismicrobepathogen

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