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Related Experiment Video

Updated: May 6, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Neural substrate responsible for crossed aphasia.

Woo Jin Kim1, Eun Joo Yang, Nam-Jong Paik

  • 1Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Rehabilitation Medicine, Inje University College of Medicine, Inje Haeundae Paik Hospital, Busan, Korea.

Journal of Korean Medical Science
|October 18, 2013
PubMed
Summary

Crossed aphasia (CA), a language deficit from right brain damage, is linked to the lentiform nucleus. This study mapped lesion sites, identifying the lentiform nucleus as the primary area responsible for CA.

Keywords:
AphasiaCrossed AphasiaLentiform NucleusStroke

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Crossed aphasia (CA) is a rare language impairment resulting from right hemisphere lesions.
  • Previous research has not detailed the specific lesion locations associated with CA.

Purpose of the Study:

  • To identify the most prevalent lesion site in patients with crossed aphasia.
  • To establish the neural substrate responsible for crossed aphasia through lesion mapping.

Main Methods:

  • Utilized brain MRI scans from 7 stroke patients diagnosed with CA.
  • Defined Regions of Interest (ROIs) and overlaid images to identify overlapping lesion areas.
  • Converted Talairach coordinates to anatomical regions, identifying significant overlap in over 3 patients.

Main Results:

  • The lentiform nucleus was identified as the most frequently affected area in CA patients.
  • Overlap was observed in the lentiform nucleus across 6 out of the 7 patient MRIs.
  • Lesion mapping successfully pinpointed significant anatomical areas associated with CA.

Conclusions:

  • This study provides the first lesion mapping analysis for crossed aphasia using brain MRI.
  • The lentiform nucleus is identified as the key neural substrate underlying crossed aphasia.