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Updated: May 6, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Alloreactivity of virus-specific T cells: possible implication of graft-versus-host disease and graft-versus-leukemia

Shigeo Fuji1, Markus Kapp, Hermann Einsele

  • 1Department of Internal Medicine II, Division of Hematology, University Hospital of Würzburg , Würzburg , Germany ; Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital , Tokyo , Japan.

Frontiers in Immunology
|October 18, 2013
PubMed

Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, we aim to give a comprehensive overview of current understanding about crossreactivity of virus-specific T cells.

Keywords:
GVHDGVLHLA antigensallogeneic stem cell transplantationmismatchvirus-specific T-cell

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