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Serum cystatin C concentration as an independent marker for hypertensive left ventricular hypertrophy

Xin Li1, Hang Zhu, Peng Li

  • 1Clinical Department of Medicine, Chinese PLA General Hospital, Beijing 100853, China.

Journal of Geriatric Cardiology : JGC
|October 18, 2013
PubMed

Insights

Serum cystatin C levels are elevated in hypertensive patients with left ventricular hypertrophy (LVH). Higher cystatin C correlates with increased heart wall thickness and mass, indicating it

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Serum cystatin C is a known predictor of cardiovascular disease morbidity and mortality.
  • The association between serum cystatin C and hypertensive left ventricular hypertrophy (LVH) remains under-investigated.
  • Understanding this relationship can offer new insights into cardiac remodeling in hypertension.

Purpose of the Study:

  • To investigate the association between serum cystatin C levels and cardiac structural and functional alterations in hypertensive patients.
  • To determine if serum cystatin C is an independent marker for LVH in hypertension.

Main Methods:

  • A cohort of 823 hypertensive patients was studied.
  • Patients were categorized into groups with (n=287) and without (n=536) LVH.
  • Echocardiography and serum cystatin C testing were performed; data were analyzed for correlations.

Main Results:

  • Serum cystatin C levels were significantly higher in hypertensive patients with LVH compared to those without.
  • Positive correlations were observed between serum cystatin C and interventricular septal thickness, posterior wall thickness, and left ventricular weight index.
  • These correlations remained significant after multiple linear regression analysis, confirming cystatin C as an independent predictor.

Conclusions:

  • Serum cystatin C concentration is an independent marker for hypertensive left ventricular hypertrophy (LVH).
  • Elevated cystatin C levels are associated with increased cardiac structural changes in hypertensive patients.
Abstract

Keywords:
Cystatin CHypertensionLeft ventricular hypertrophy

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