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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
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Updated: May 6, 2026

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DNA replication: polymerases

John Brunstein1

  • 1PathoID, Inc., British Columbia.

MLO: Medical Laboratory Observer
|October 19, 2013
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Summary

No abstract available in PubMed .

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