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[Study on quality standard for mori cortex].

Zhi-Tao Duan1, Ying Gao, Gang Zhou

  • 1School of Chinese Materia Medica, Guangzhou University of TCM, Guangzhou 510006, China. dzt8716@163.com

Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|October 19, 2013
PubMed
Summary
This summary is machine-generated.

This study developed a reliable method to evaluate Mori Cortex quality. The established method accurately quantifies key compounds, revealing variations based on habitat and harvest time.

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Area of Science:

  • Pharmacognosy
  • Analytical Chemistry

Context:

  • Mori Cortex (mulberry bark) is a traditional medicine with variable active compound levels.
  • Standardized quality control is essential for ensuring therapeutic efficacy and safety.

Purpose:

  • To establish a robust analytical model for evaluating Mori Cortex.
  • To compare the chemical profiles of Mori Cortex from diverse origins and harvest periods.
  • To validate the accuracy and reliability of the developed quality control method.

Summary:

  • Thin-layer chromatography (TLC) and High-Performance Liquid Chromatography (HPLC) methods were established for identifying and quantifying key compounds like sanggenon D, sanggenon C, and 1-deoxynojirimycin (DNJ).
  • The methods demonstrated good linearity, recovery rates (97.4-99.1%), and precision (RSD < 2.6%), confirming their suitability for quality control.
  • Significant variations in the content of these index components were observed in Mori Cortex samples from different habitats and harvest times.

Impact:

  • Provides a reliable and accurate analytical method for the quality control of Mori Cortex.
  • Enables differentiation of Mori Cortex based on geographical origin and harvest season.
  • Supports the standardization of Mori Cortex for pharmaceutical and nutraceutical applications.