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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Diffuse dermal melanocytosis in two patients with Sandhoff disease and mucopolysaccharidosis VI
Mahmoud Reza Ashrafi1, Alireza Tavasoli, Shadi Shiva
1Department of Pediatrics, Children's Medical Center, Tehran, Iran.
Abstract:
Dermal melanocytosis (DM) is described as the presence of ectopic melanocytes in the dermis and could be a normal cutaneous finding. However, diffuse DM or extensive Mongolian spots must be considered as an early sign of neurometabolic diseases, in particular lysosomal storage disorders. The presence of extensive DM should alert the physician to the presence of such disorders, making early diagnosis possible. We describe for the first time the presence of DM in two patients with Sandhoff disease and mucopolysaccharidosis VI.
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