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Updated: May 6, 2026

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Published on: May 7, 2011
Systemic capillary leak syndrome: recognition prevents morbidity and mortality
D J Rabbolini1, N Ange, G D Walters
1Department of Haematology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia.
Abstract:
Idiopathic systemic capillary leak syndrome (SCLS) is extremely rare but carries a high morbidity and mortality. The diagnosis is made clinically by a classic triad of hypotension, hypoalbuminaemia and haemoconcentration. There have been recent advances in understanding the pathophysiological basis for SCLS and in effective prophylaxis. We report a case of SCLS to increase awareness of the condition and to highlight the benefits of prophylactic intravenous immunoglobulin in this condition.
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