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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Basophil Activation Test for Allergy Diagnosis
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Egg allergy: an update.

John W Tan1, Preeti Joshi

  • 1Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia.

Journal of Paediatrics and Child Health
|October 19, 2013
PubMed
Summary
This summary is machine-generated.

Egg allergy is a common infant condition causing various reactions, including anaphylaxis and atopic dermatitis. This review covers diagnosis, management, and future therapies for egg allergy.

Keywords:
allergyanaphylaxiseggfood

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Area of Science:

  • Pediatric Allergy and Immunology
  • Clinical Immunology
  • Food Hypersensitivity Research

Background:

  • Egg allergy represents the most prevalent food allergy in infants globally and in Australia.
  • It manifests through diverse clinical presentations, involving both IgE and non-IgE mediated pathways.
  • Egg allergy is associated with severe conditions like anaphylaxis, food protein-induced enterocolitis syndrome, atopic dermatitis, and eosinophilic oesophagitis.

Purpose of the Study:

  • To comprehensively review the clinical presentation, pathophysiology, and diagnosis of egg allergy.
  • To discuss the natural history and current management strategies for egg allergy.
  • To explore emerging theories on primary prevention and future therapeutic interventions for egg allergy.

Main Methods:

  • Literature review of clinical presentations, pathophysiology, and diagnostic approaches.
  • Analysis of natural history and established management protocols.
  • Synthesis of current research on primary prevention and novel therapies.

Main Results:

  • Egg allergy presents a wide spectrum of clinical manifestations.
  • Both IgE and non-IgE mediated mechanisms contribute to egg allergy.
  • Effective management strategies and diagnostic criteria are crucial for patient outcomes.

Conclusions:

  • Egg allergy requires a multifaceted approach encompassing diagnosis, management, and prevention.
  • Ongoing research into pathophysiology and novel therapies holds promise for improved patient care.
  • Understanding the natural history is key to optimizing treatment and outcomes for infants with egg allergy.