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Updated: May 6, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Unexpected copper-catalyzed cascade synthesis of quinazoline derivatives
Zhongyan Chen1, Jiuxi Chen, Miaochang Liu
1College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
Abstract:
The first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.
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