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Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Burn Injuries

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Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Related Experiment Video

Updated: May 6, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Therapy of pathological scars.

Justinus A Wagner¹

¹Department of Dermatology, Venereology and Allergology, Leipzig University Hospital, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

|October 19, 2013

Summary

Preventing excessive scarring is more effective than treating it. This overview covers scar pathogenesis, classification, prevention, and various therapeutic options for physicians.

Area of Science:

Dermatology
Wound Healing
Plastic Surgery

Background:

Scarring presents diverse clinical manifestations relevant across medical disciplines.
Effective management hinges on timely intervention, with prevention yielding better outcomes than post-scarring treatment.

Purpose of the Study:

To provide a comprehensive overview of scar management.
To detail scar pathogenesis, classification, documentation, and therapeutic strategies.

Main Methods:

Literature review and synthesis of current knowledge on scar management.
Inclusion of both invasive and non-invasive therapeutic modalities.

Main Results:

Prevention strategies are crucial for minimizing excessive scarring.

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Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

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In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

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Last Updated: May 6, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

A range of options exist for wound repair modulation and scar treatment.

Conclusions:

Understanding scar pathogenesis and classification is key for effective management.
A multi-faceted approach combining prevention and treatment is recommended for optimal outcomes.