Akaeolide, a carbocyclic polyketide from marine-derived Streptomyces
Yasuhiro Igarashi1, Tao Zhou, Seizo Sato
1Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University , 5180 Kurokawa, Imizu, Toyama 939-0398, Japan , Central Research Laboratory, Nippon Suisan Kaisha, Ltd., Tokyo Innovation Center , 1-32-3 Nanakuni, Hachioji, Tokyo 192-0991, Japan , and Application Laboratories, Rigaku Corporation , 3-9-12 Matsubara-cho, Akishima, Tokyo 196-8666, Japan.
Abstract:
Akaeolide, a novel polycyclic polyketide, was isolated from the culture extract of a marine-derived actinomycete belonging to the genus Streptomyces. The planar structure of the new compound was elucidated by spectroscopic analysis including NMR and MS, and the absolute configuration was determined by X-ray crystallographic analysis of its chlorinated derivative. Akaeolide possesses a 15-membered carbocyclic framework, apparently derived from the malonate pathway, with a tetrahydrofuran ring and a β-keto-δ-lactone unit.
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