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Nanotherapeutic approaches for brain cancer management
Laura Saenz del Burgo1, Rosa María Hernández1, Gorka Orive1
1NanoBioCel Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, UPV/EHU Vitoria-Gasteiz, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Vitoria-Gasteiz, Spain.
Unlabelled:
Around the world, cancer remains one of the most important causes of morbidity and mortality. Worldwide, approximately 238,000 new cases of brain and other central nervous system tumors are diagnosed every year. Nanotherapeutic approaches hold tremendous potential for diagnosis and treatment of brain cancer, including the ability to target complex molecular cargoes to the tumor sites and the capacity of crossing the blood-brain barrier and accessing to the brain after systemic administration. A new generation of "smart" nanoparticles has been designed as novel targeted delivery devices for new therapies including gene therapy, anti-angiogenic and thermotherapy. This review highlights the latest research, opportunities and challenges for developing novel nanotherapeutics for treating brain cancers.
From The Clinical Editor:
This comprehensive review highlights the latest research results, opportunities and challenges for developing novel nanotherapeutics for treating brain cancers, with a special focus on "smart" nanoparticles as novel targeted delivery devices for new therapies including gene therapy, anti-angiogenic therapy and localized thermotherapy.
Insights
Smart nanoparticles offer new hope for brain cancer treatment by targeting tumors and crossing the blood-brain barrier. This review explores advanced nanotherapeutics for gene therapy, anti-angiogenic therapy, and thermotherapy.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Cancer is a leading cause of death globally, with brain tumors affecting approximately 238,000 individuals annually.
- Nanotherapeutics show promise for brain cancer treatment due to their ability to target tumors and cross the blood-brain barrier.
- Smart nanoparticles represent a new frontier in targeted drug delivery for central nervous system malignancies.
Purpose of the Study:
- To review the latest advancements in nanotherapeutics for brain cancer.
- To highlight the potential of "smart" nanoparticles in targeted drug delivery.
- To discuss opportunities and challenges in developing novel nanotherapies for brain cancers.
Main Methods:
- Literature review of recent research on nanotherapeutics for brain cancer.
- Focus on "smart" nanoparticles and their applications in targeted delivery.
- Analysis of therapeutic strategies including gene therapy, anti-angiogenic therapy, and thermotherapy.
Main Results:
- Smart nanoparticles are being developed as advanced delivery systems for brain cancer treatment.
- These nanoparticles can target tumor sites and overcome the blood-brain barrier.
- Nanotherapeutics offer potential for novel therapies like gene therapy, anti-angiogenic therapy, and thermotherapy.
Conclusions:
- Nanotherapeutic approaches, particularly using smart nanoparticles, hold significant potential for treating brain cancers.
- Further research is needed to address the challenges in developing and implementing these novel therapies.
- The review underscores the opportunities for innovative treatments in neuro-oncology.
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