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Published on: May 24, 2021
Effects of MLC601 on early vascular events in patients after stroke: the CHIMES study
Christopher L H Chen1, Narayanaswamy Venketasubramanian, Chun Fan Lee
1From the Department of Pharmacology, National University of Singapore, Singapore (C.L.H.C.); Raffles Neuroscience Centre, Raffles Hospital, Singapore (N.V.); Singapore Clinical Research Institute, Singapore (C.F.L.); Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories (K.S.L.W.); Lariboisière University Hospital, Paris, France (M.-G.B.).
Insights
MLC601 significantly reduced early vascular events, including recurrent stroke and vascular death, within three months after ischemic stroke. This neuroprotective treatment shows promise in preventing post-stroke complications.
Area of Science:
- Neurology
- Cardiology
- Clinical Pharmacology
Background:
- Early vascular events are a major cause of morbidity and mortality post-stroke.
- Preventing these events in the first three months is critical for patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of MLC601 in reducing early vascular events after ischemic stroke.
- To analyze the impact of MLC601 on composite vascular outcomes within 90 days of stroke onset.
Main Methods:
- A post hoc analysis of the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study.
- Included 1099 patients with ischemic stroke treated within 72 hours.
- Compared MLC601 versus placebo in a randomized, double-blinded trial.
Main Results:
- MLC601 group had significantly fewer early vascular events (2.9%) compared to placebo (5.6%) (P=0.025).
- Kaplan-Meier analysis revealed a significant difference in vascular outcomes as early as one month post-stroke (HR=0.51, P=0.024).
- No increase in nonvascular deaths was observed in the MLC601 group.
Conclusions:
- MLC601 treatment is associated with a reduction in early vascular events following ischemic stroke.
- Further research is needed to elucidate the mechanisms underlying MLC601's protective effects.
Background And Purpose:
Early vascular events are an important cause of morbidity and mortality in the first 3 months after a stroke. We aimed to investigate the effects of MLC601 on the occurrence of early vascular events within 3 months of stroke onset.
Methods:
Post hoc analysis was performed on data from subjects included in the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study, a randomized, placebo-controlled, double-blinded trial that compared MLC601 with placebo in 1099 subjects with ischemic stroke of intermediate severity in the preceding 72 hours. Early vascular events were defined as a composite of recurrent stroke, acute coronary syndrome, and vascular death occurring within 3 months of stroke onset.
Results:
The frequency of early vascular events during the 3-month follow-up was significantly less in the MLC601 group than in the placebo group (16 [2.9%] versus 31 events [5.6%]; risk difference=-2.7%; 95% confidence interval, -5.1% to -0.4%; P=0.025) without an increase in nonvascular deaths. Kaplan-Meier survival analysis showed a difference in the risk of vascular outcomes between the 2 groups as early as the first month after stroke (Log-rank P=0.024; hazard ratio, 0.51; 95% confidence interval, 0.28-0.93).
Conclusions:
Treatment with MLC601 was associated with reduced early vascular events among subjects in the CHIMES study. The mechanisms for this effect require further study.
Clinical Trial Registration Url:
http://www.clinicaltrials.gov. Unique identifier: NCT00554723.
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