Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

3.0K
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
3.0K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

64.7K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
64.7K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

5.1K
5.1K
Ion Exchange01:17

Ion Exchange

1.6K
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
1.6K
Ion Channels01:19

Ion Channels

68.1K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
68.1K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

4.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioorthogonal Photoactivation of 2-Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Identification of phenotypes and predictors for dyspnea, echocardiographic probability of pulmonary hypertension, and confirmed CTEPH in patients with acute pulmonary embolism: Analysis of two large patient cohorts.

Thrombosis research·2025
Same author

Modern treatment of craniopharyngioma to improve outcomes: evidence of a change of paradigm.

Endocrine·2025
Same author

Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE.

Nature communications·2025
Same author

Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain.

Nanomedicine (London, England)·2023
Same author

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration.

Developmental cell·2023

Related Experiment Video

Updated: May 6, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

9.0K

Ferrocene-based multichannel ion-pair recognition receptors.

Pedro Molina1, Alberto Tárraga, María Alfonso

  • 1Departamento de Química Orgánica, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain. pmolina@um.es.

Dalton Transactions (Cambridge, England : 2003)
|October 19, 2013
PubMed
Summary
This summary is machine-generated.

Ferrocenylimidazoles and ferrocenes with triazole rings act as effective receptors for recognizing ion pairs. These compounds demonstrate significant potential in sensing and molecular recognition applications.

More Related Videos

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
08:54

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Published on: August 9, 2024

1.1K
Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

7.4K

Related Experiment Videos

Last Updated: May 6, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

9.0K
Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
08:54

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Published on: August 9, 2024

1.1K
Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

7.4K

Area of Science:

  • Organometallic Chemistry
  • Supramolecular Chemistry
  • Analytical Chemistry

Background:

  • Ferrocene derivatives are widely studied due to their unique redox properties and versatile coordination chemistry.
  • Developing selective receptors for ion-pair recognition is crucial for various analytical and biological applications.
  • Incorporating heterocyclic moieties like triazoles can modulate the electronic and binding properties of ferrocene-based systems.

Purpose of the Study:

  • To synthesize and characterize novel ferrocenylimidazole and 1,1'-disubstituted ferrocene derivatives.
  • To investigate the ion-pair recognition capabilities of these new compounds.
  • To explore the influence of the triazole ring directly linked to the ferrocene redox unit on receptor performance.

Main Methods:

  • Synthesis of ferrocenylimidazole and unsymmetrical 1,1'-disubstituted ferrocene compounds.
  • Spectroscopic characterization (NMR, IR, Mass Spectrometry) and electrochemical analysis (cyclic voltammetry).
  • Ion-pair binding studies using techniques such as UV-Vis spectroscopy and electrochemical methods.

Main Results:

  • The synthesized ferrocenylimidazoles and ferrocenes effectively recognized specific ion pairs.
  • The direct linkage of the triazole ring to the ferrocene redox unit enhanced ion-pair binding affinity and selectivity.
  • Electrochemical studies confirmed the role of the ferrocene redox center in the recognition process.

Conclusions:

  • Ferrocenylimidazoles and unsymmetrically substituted ferrocenes bearing a directly linked triazole ring are efficient ion-pair recognition receptors.
  • These findings highlight the potential of tailored ferrocene-triazole conjugates for developing advanced molecular sensors and separation materials.