Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Bacteriophages

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The landscape of antibody production systems: recombinant expression for research, diagnostics and therapy.

Frontiers in bioengineering and biotechnology·2026

Same author

Phase I Study Evaluating a Monoclonal Fc-Silenced SARS-CoV-2 Antibody in Patients With Moderate-to-Severe COVID-19.

Clinical therapeutics·2026

Same author

Resolving the Interference of Anti-CD38 Antibodies on Blood Compatibility Assays Using CD38 "Baitbodies" Approach.

Journal of immunology research·2026

Same author

Immunogenic <i>Streptococcus equi</i> cell surface proteins identified by ORFeome phage display.

mSphere·2025

Same author

Phage Display Derived Antibodies Against Antimicrobial Peptide FsPDF2 Reveal Stress Response in European Beech.

Plant biotechnology journal·2025

Same author

Modeling and optimization of bioproduct formation with purple phototrophic bacteria using machine learning.

Bioresource technology·2025

Search research articles

Related Experiment Video

Updated: May 6, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

Oligopeptide m13 phage display in pathogen research.

Jonas Kügler¹, Jonas Zantow, Torsten Meyer

¹Technische Universität Braunschweig, Institut für Biochemie, Biotechnologie und Bioinformatik, Abteilung Biotechnologie, Spielmannstr. 7, 38106 Braunschweig, Germany. m.hust@tu-bs.de.

|October 19, 2013

Summary

Oligopeptide phage display offers a novel method for identifying pathogen antigens, advancing diagnostics and vaccine development. This technique provides new insights into host-pathogen interactions and aids in creating innovative medical solutions.

More Related Videos

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Published on: December 6, 2017

A Protocol for Phage Display and Affinity Selection Using Recombinant Protein Baits

A Protocol for Phage Display and Affinity Selection Using Recombinant Protein Baits

Published on: February 16, 2014

Related Experiment Videos

Last Updated: May 6, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Published on: December 6, 2017

A Protocol for Phage Display and Affinity Selection Using Recombinant Protein Baits

A Protocol for Phage Display and Affinity Selection Using Recombinant Protein Baits

Published on: February 16, 2014

Area of Science:

Biotechnology
Immunology
Microbiology

Background:

Phage display is a common technique for selecting peptides and antibodies.
Using phage display to select pathogen antigens is less recognized than traditional methods.

Purpose of the Study:

To review the application of M13 oligopeptide phage display for pathogen research.
To highlight new antigen discoveries and their potential in diagnostics and vaccines.

Main Methods:

Focus on M13 oligopeptide phage display system.
Includes examples of lambda phage display and other disease-related applications.
Provides a technical workflow for identifying immunogenic oligopeptides using the pHORF system.

Main Results:

Oligopeptide phage display has led to the identification of various new antigens.
These antigens offer insights into host-pathogen interactions.
Identified proteins can be used for developing new diagnostic tests and vaccines.

Conclusions:

Oligopeptide phage display is a valuable tool for pathogen research.
This method can be integrated with antibody phage display to create a vaccine pipeline.
Novel antigens identified can significantly contribute to medical advancements.