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Updated: May 6, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Facile regioselective synthesis of novel bis-thiazole derivatives and their antimicrobial activity
Nosrat O Mahmoodi1, Jafar Parvizi, Bahman Sharifzadeh
1Faculty of Sciences, Department of Organic Chemistry, University of Guilan, Rasht, Iran.
Abstract:
The design and synthesis of several new bis-thiazoles 4a-h serving as bis-drugs in comparison with mono-heterocyclic analogs are described. These bis-drugs present superior medicinal and pharmacological activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with higher hydrophobicity. Compounds with higher hydrophobicity (4d and 4h) exhibited some activity against the gram-negative bacteria.
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