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Thromboangiitis obliterans in two brothers.
Qi-Lin Li1, Dan-Hua He, Yong-Hua Huang
1Department of Dermatology, Fourth Affiliated Hospital of Jinan University, Guangzhou Red Cross Hospital, Guangzhou, Guangdong 510220, P.R. China.
Experimental and Therapeutic Medicine
|October 19, 2013
Summary
Thromboangiitis obliterans (TAO) treatment involving herbal compounds and growth factors showed mixed results. One patient experienced symptom improvement, while the other showed disease progression and severe complications.
Area of Science:
- Vascular Medicine
- Dermatology
- Immunology
Background:
- Thromboangiitis obliterans (TAO), also known as Buerger's disease, is a rare inflammatory disease affecting blood vessels, primarily in the hands and feet.
- Erythema nodosum can be associated with various underlying conditions, including inflammatory and autoimmune disorders.
Purpose of the Study:
- To report the treatment outcomes of two brothers diagnosed with thromboangiitis obliterans (TAO) presenting with erythema nodosum.
- To evaluate the efficacy of a multi-component treatment regimen including herbal medicines, growth factors, and immunomodulatory agents.
Main Methods:
- Two patients diagnosed with TAO and erythema nodosum received treatment with Danshen Dripping Pills, Fufang Danshen Diwan, Salvia tetramethylpyrazine, fibroblast growth factor, Bayaspirin, Bacillus Calmette-Guérin polysaccharide nucleic acid fraction, and compound glycyrrhizin tablets.
- Clinical outcomes, including pain levels, ulcer size, pus secretion, inflammation, and signs of gangrene, were monitored.
Main Results:
- Case 2 showed reduced left foot pain, decreased ulcer size on the first toe, and diminished pus and inflammation.
- Case 1 experienced reduced pus secretion but showed ulcer enlargement, spread to the fifth toe with gangrene, and exposed, broken tendons causing severe pain.
Conclusions:
- The combination therapy demonstrated partial efficacy in one TAO patient but was insufficient to halt disease progression in the other, highlighting the complex and variable nature of TAO.
- Further research is needed to optimize treatment strategies for thromboangiitis obliterans, particularly in cases with severe manifestations.
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