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Related Experiment Video

Updated: May 6, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Dual-source computed tomography for evaluating coronary stenosis and left ventricular function.

Chunfeng Hu1, Jie Wang, Kai Xu

  • 1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029; ; Department of Radiology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221006, P.R. China.

Experimental and Therapeutic Medicine
|October 19, 2013
PubMed
Summary
This summary is machine-generated.

Dual-source computed tomography coronary angiography (DSCT CAG) accurately assesses coronary stenosis and its impact on left ventricular function. DSCT CAG reveals significant changes in cardiac parameters with increasing severity of coronary artery disease.

Keywords:
coronary stenosisdual-source computed tomographyechocardiographyleft ventricular function

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Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Coronary artery disease (CAD) affects cardiac function.
  • Accurate assessment of coronary stenosis and its functional impact is crucial for patient management.

Purpose of the Study:

  • To evaluate the correlation between coronary stenosis severity and left ventricular function using dual-source computed tomography coronary angiography (DSCT CAG).
  • To compare the diagnostic accuracy of DSCT CAG with conventional methods like selective CAG and echocardiography (ECHO).

Main Methods:

  • DSCT CAG was performed on 66 patients with coronary disease and 36 healthy volunteers.
  • Left ventricular parameters including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and myocardial mass (MM) were measured.
  • Results were compared against selective CAG and ECHO as control methods.

Main Results:

  • DSCT CAG showed no significant difference in diagnosing coronary stenosis compared to selective CAG (P>0.05).
  • DSCT CAG measurements of EDV, ESV, and SV were comparable to ECHO findings (P>0.05).
  • Significant differences in ESV, EF, and SV were observed in the severe stenosis group compared to mild and moderate groups (P<0.05). EDV and MM varied significantly across stenosis severity groups (P<0.05).

Conclusions:

  • DSCT CAG is a highly accurate and reproducible method for assessing preliminary cardiac function changes related to coronary stenosis.
  • Significant alterations in left ventricular EDV and MM were detected in moderate stenosis, with comprehensive changes in all parameters observed in severe stenosis.