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Updated: May 6, 2026

Characterization of a Novel Human Organotypic Retinal Culture Technique
Published on: June 9, 2021
[Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy]
Abstract:
A considerable tear endothelin-1 increase (2-3 times) has been found in patients with primary open-angle glaucoma and proliferative diabetic retinopathy. Patients with proliferative retinopathy also showed an increase of plasminogen level in tear fluid and a tendency of a similar increase in blood serum. No correlation between endothelin-1 and plasminogen levels in these pathologies was established. Tear endothelin-1 and plasminogen measurement could be used as an informative and non-invasive method to help prognosis making, condition severity evaluation and control the effectiveness of treatment of ocular local microcirculatory disturbances.
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