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Updated: May 6, 2026
Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
A chemodosimeter for the ratiometric detection of hydrazine based on return of ESIPT and its application in live-cell
Shyamaprosad Goswami1, Sangita Das, Krishnendu Aich
1Department of Chemistry, Bengal Engineering and Science University, Shibpur , Howrah 711103, West Bengal, India and Department of Microbiology, The University of Burdwan , Burdwan 713101, West Bengal, India.
Abstract:
A probe based on 2-(2'-hydroxyphenyl) benzothiazole (HBT) has been synthesized and used for the ratiometric detection of hydrazine. The probe is designed in such a way that the excited state intramolecular proton transfer (ESIPT) of the HBT moiety gets blocked. The chemodosimetric approach of hydrazine to the probe results in the recovery of the ESIPT by removal of a free HBT moiety through subsequent substitution, cyclization, and elimination processes. The probe is successfully demonstrated to enable the detection of hydrazine in live cells.
