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Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

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Updated: May 6, 2026

Analysis and Specification of Starch Granule Size Distributions

Analysis and Specification of Starch Granule Size Distributions

Published on: March 4, 2021

Interaction between hydroxyethyl starch and propofol: computational and laboratorial study.

Aura Silva¹, Emília Sousa, Andreia Palmeira

¹a REQUIMTE, Toxicology, Faculdade de Farmácia da , Universidade do Porto , Rua de Jorge Viterbo Ferreira, 228, Porto , 4050-313 , Portugal .

Journal of Biomolecular Structure & Dynamics

|October 22, 2013

Summary

This summary is machine-generated.

Hydroxyethyl starch (HES) and propofol form a complex, reducing propofol levels in plasma. This interaction, confirmed by spectroscopy and docking, may impact anesthetic drug efficacy.

Keywords:

hydroxyethyl starch infrared spectroscopy magnetic resonance spectroscopy propofol ultraviolet spectroscopy

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Area of Science:

Anesthesiology
Pharmacology
Biochemistry

Background:

Hydroxyethyl starch (HES) is a widely used colloid for intravascular volume replacement during anesthesia.
Understanding potential drug interactions is crucial for patient safety in perioperative care.

Purpose of the Study:

To investigate potential chemical interactions between Hydroxyethyl starch (HES) and the anesthetic propofol.
To characterize the complex formed between HES and propofol using various analytical techniques.

Main Methods:

In vitro propofol dosing in plasma samples with HES or lactated Ringer's solution.
Computational docking studies to predict binding interactions between HES and propofol.
Spectroscopic analysis (IR, UV, NMR) of propofol-HES mixtures.

Main Results:

Significantly lower propofol concentrations were observed in HES-containing samples compared to controls.
Spectroscopic data and docking studies indicated a potential interaction and complex formation between propofol and HES.
The propofol-HES complex exhibited distinct physical-biochemical properties.

Conclusions:

Propofol and HES form a complex with altered properties, suggesting a significant drug interaction.
This interaction may influence the clinical efficacy and safety of propofol during anesthesia.
Further clinical studies are warranted to evaluate the implications of this propofol-HES interaction.