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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Combined Effects of Drugs: Synergism01:27

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: May 6, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Combination therapy: the propitious rationale for drug development.

Neetu Phougat, Savita Khatri, Anu Singh

  • 1Centre for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana-124001, India. anil.chhillar@gmail.com.

Combinatorial Chemistry & High Throughput Screening
|October 22, 2013
PubMed
Summary
This summary is machine-generated.

The pipeline for new antimicrobial drugs is critically low, risking a return to a pre-antibiotic era. Combination drug therapy offers a promising strategy to combat evolving resistant pathogens.

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Area of Science:

  • Microbiology and Infectious Diseases
  • Pharmacology and Drug Development
  • Public Health

Background:

  • The increasing prevalence of antimicrobial resistance poses a significant global health crisis.
  • There is a critical shortage of novel antimicrobial agents in the drug development pipeline.
  • Existing and emerging infectious diseases present a substantial threat due to limited therapeutic options.

Purpose of the Study:

  • To review the challenges associated with the discovery and development of new antimicrobial drugs.
  • To highlight the potential of combination drug therapy as a viable strategy against resistant pathogens.
  • To emphasize the urgent need for innovative approaches in antimicrobial drug development.

Main Methods:

  • Literature review of current antimicrobial drug development status.
  • Analysis of challenges in discovering, characterizing, and developing new antimicrobials.
  • Examination of successful combination therapies in infectious disease management.

Main Results:

  • Few new antibiotics have been approved in recent years, with limited drugs in development.
  • Many new drug candidates face issues with toxicity, pharmacokinetics, or pharmacodynamics.
  • Combination therapies, including repurposed drugs, show promise in overcoming resistance.

Conclusions:

  • The development of new antimicrobial agents is decades behind the pace of bacterial evolution.
  • Combination therapy represents a vital and promising approach to manage infectious diseases caused by resistant microbes.
  • Urgent innovation in antimicrobial strategies is essential to avert a public health emergency.