Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The TriVersa NanoMate: Automation of Nano Electrospray Analyses.

Mass spectrometry reviews·2026
Same author

A Personal Perspective on the Evolution of Today's LC/MS Techniques.

Journal of the American Society for Mass Spectrometry·2026
Same author

Ratio of non-protein calories to grams of amino acids and amino acid blood levels in preterm infants receiving parenteral nutrition.

Journal of neonatal-perinatal medicine·2025
Same author

N-Acetyltyrosine as a Biomarker of Parenteral Nutrition Administration in First-Tier Newborn Screening Assays.

International journal of neonatal screening·2024
Same author

Multiplatform Metabolomics: Enhancing the Severity Risk Prognosis of SARS-CoV-2 Infection.

ACS omega·2024
Same author

An analytical approach for on-site analysis of breath samples for Δ9-tetrahydrocannabinol (THC).

Journal of mass spectrometry : JMS·2023

Related Experiment Video

Updated: May 6, 2026

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins
10:21

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins

Published on: January 13, 2023

2.8K

Microsample analyses via DBS: challenges and opportunities.

Jack Henion1, Regina V Oliveira, Donald H Chace

  • 1Quintiles BioAnalytical & ADME Labs, a Quintiles Company, 19 Brown Rd, Ithaca, NY 14850, USA.

Bioanalysis
|October 22, 2013
PubMed
Summary
This summary is machine-generated.

Dried blood spot (DBS) microsampling offers a minimally invasive, cost-effective, and highly sensitive bioanalysis method. Its utility is expanding beyond newborn screening into pharmaceutical research, highlighting its future potential.

More Related Videos

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

10.5K
Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

46.1K

Related Experiment Videos

Last Updated: May 6, 2026

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins
10:21

Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins

Published on: January 13, 2023

2.8K
Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

10.5K
Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

46.1K

Area of Science:

  • Analytical Chemistry
  • Biomedical Science
  • Pharmacology

Background:

  • Dried blood spot (DBS) microsampling has been utilized for over 50 years in metabolic screening.
  • DBS offers minimally invasive and economical sample collection.
  • LC-MS technology provides high sensitivity, selectivity, and multianalyte capabilities for DBS analysis.

Purpose of the Study:

  • To review the benefits and applications of DBS microsampling techniques in bioanalysis.
  • To explore the growing utility of DBS in the pharmaceutical industry and other research areas.
  • To discuss the future prospects and potential applications of DBS technology.

Main Methods:

  • Review of existing literature on DBS microsampling and LC-MS bioanalysis.
  • Analysis of DBS applications in newborn screening and metabolic studies.
  • Exploration of emerging applications in the pharmaceutical sector.

Main Results:

  • DBS requires only microliters of biological fluid, reducing sample demands.
  • LC-MS coupled with DBS demonstrates high sensitivity, selectivity, and multianalyte detection.
  • DBS microsampling is increasingly being adopted by the pharmaceutical industry.

Conclusions:

  • DBS microsampling is a valuable technique for bioanalysis due to its efficiency and sensitivity.
  • The application of DBS is expanding, with significant potential in pharmaceutical research and development.
  • DBS techniques are poised to become a standard in future bioanalytical workflows.