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An overview of cardiac morphogenesis.
Jean-Marc Schleich1, Tariq Abdulla, Ron Summers
1Service de Cardiologie et de Maladies Vasculaires, Hôpital de Pontchaillou, 35033 Rennes cedex 09, France; INSERM U 1099, Université de Rennes, LTSI, 35042 Rennes, France.
Archives of Cardiovascular Diseases
|October 22, 2013
Summary
Understanding normal heart development is key to diagnosing congenital heart defects. This review details cardiac morphogenesis, septation, and links between developmental abnormalities and common heart defects in newborns.
Area of Science:
- Developmental Biology
- Cardiovascular Science
- Embryology
Background:
- Congenital cardiac malformations are the most common anomaly in newborns.
- Accurate knowledge of normal cardiac development is essential for understanding these defects.
- The heart forms early in embryonic development, functioning by 8 weeks of gestation.
Purpose of the Study:
- To review the key steps in embryonic heart development.
- To focus on the processes of alignment and septation.
- To link cardiac developmental abnormalities to congenital heart defects.
Main Methods:
- Review of recent molecular genetics studies on cellular precursors.
- Analysis of the processes of alignment and septation in heart development.
- Examination of data from animal models of cardiac malformations.
Main Results:
- Molecular genetics has clarified the roles of cellular precursors in heart development.
- Specific links between abnormal development and congenital heart defects are identified.
- Animal models have revealed mechanisms underlying cardiac malformations.
Conclusions:
- A comprehensive understanding of cardiac development is crucial for addressing congenital heart defects.
- Further research, potentially including multiscale cardiac modeling, is needed.
- This review synthesizes current knowledge on heart morphogenesis and related defects.
Keywords:
AVAtrioventricularCardiac morphogenesisCardiopathies congénitalesCongenital heart defectsDéveloppement cardiaque normalEmbryologieEmbryologyFHFFirst heart fieldMorphogenèse cardiaqueNormal heart developmentOTOutflow tractSHFSecond heart fieldVSDVentricular septal defectWGWeek(s) of gestation
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