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Updated: May 6, 2026

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
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IL-9 by INFERence.

Baohua Zhou1, Mark H Kaplan

  • 1Department of Pediatrics and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Immunity
|October 22, 2013
PubMed
Summary
This summary is machine-generated.

Researchers identified the source of interleukin-9 (IL-9) by discovering IL-9-secreting T cells. These cells play a crucial role in immunity against helminthic parasites, providing new insights into immune responses.

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Area of Science:

  • Immunology
  • Cell Biology
  • Parasitology

Background:

  • The biological sources of the cytokine interleukin-9 (IL-9) have been unknown for over two decades.
  • Understanding IL-9's origin is critical for elucidating its role in immune responses.

Purpose of the Study:

  • To identify the specific cell types responsible for producing interleukin-9 (IL-9).
  • To investigate the function of IL-9-producing cells in the context of parasitic infections.

Main Methods:

  • Generation of a novel reporter mouse model to track IL-9 expression.
  • Analysis of immune cell populations and their cytokine production during helminthic parasite infection.

Main Results:

  • Demonstrated that T cells are a major source of IL-9.
  • Showcased the involvement of IL-9-secreting T cells in mounting an effective immune response against helminthic parasites.

Conclusions:

  • T cells are identified as key biological sources of interleukin-9 (IL-9).
  • IL-9-producing T cells are essential for host defense against helminthic parasites, advancing our understanding of IL-9's immunological functions.