Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapy changes in the treatment of subglottic laryngitis: A 30-year experience in Croatia.

International journal of pediatric otorhinolaryngology·2026
Same author

Regulation of NAT1 activity in modern humans by a novel phosphorylation site.

Science advances·2026
Same author

The Use of Topical Lidocaine Versus Lidocaine Injection for Myringotomy and Ventilation Tube Insertion.

Medicina (Kaunas, Lithuania)·2026
Same author

Spatiotemporal cellular map of the developing human reproductive tract.

Nature·2025
Same author

Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephaly.

EMBO reports·2025
Same author

ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development.

Cell reports·2025

Related Experiment Video

Updated: May 6, 2026

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation
07:03

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Published on: May 6, 2020

5.6K

Progenitor networking in the fetal primate neocortex.

Wieland B Huttner1, Iva Kelava, Eric Lewitus

  • 1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany.

Neuron
|October 22, 2013
PubMed
Summary

Four basal radial glia (bRG) subtypes in the fetal macaque neocortex generate neurons. This study reveals unexpected complexity in neural stem cell lineages during primate brain development.

More Related Videos

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

12.5K
Neonatal Pial Surface Electroporation
06:22

Neonatal Pial Surface Electroporation

Published on: May 7, 2014

13.4K

Related Experiment Videos

Last Updated: May 6, 2026

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation
07:03

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Published on: May 6, 2020

5.6K
Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

12.5K
Neonatal Pial Surface Electroporation
06:22

Neonatal Pial Surface Electroporation

Published on: May 7, 2014

13.4K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Basal radial glia (bRG) are a major type of neural stem cell identified in the fetal primate neocortex.
  • Understanding the diversity and function of bRG is crucial for comprehending human brain evolution and development.

Purpose of the Study:

  • To identify and characterize distinct subtypes of basal radial glia (bRG) in the fetal macaque neocortex.
  • To investigate the lineage potential and contribution of different bRG subtypes to neuronal generation.

Main Methods:

  • Morphological analysis of neural progenitor cells in the fetal macaque neocortex.
  • Lineage tracing techniques to track cell fate and neuronal production.
  • Analysis of cell proliferation and differentiation patterns.

Main Results:

  • Identification of four morphologically distinct basal radial glia (bRG) subtypes in the outer subventricular zone.
  • Demonstration that these bRG subtypes exhibit differential contributions to neuronal populations.
  • Unexpected complexity in the lineages generating neurons from bRG populations was revealed.

Conclusions:

  • The fetal primate neocortex harbors a greater diversity of basal radial glia (bRG) than previously recognized.
  • Distinct bRG subtypes play specialized roles in generating neuronal diversity.
  • These findings challenge previous models and highlight the intricate mechanisms of primate neurogenesis.