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Ureaplasma--Are you sitting comfortably?

Amanda Gwee1, Nigel Curtis

  • 1Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria 3052, Australia.

The Journal of Infection
|October 22, 2013
PubMed

Insights

Ureaplasma species, often normal flora, can cause urogenital infections and serious perinatal complications. This review covers Ureaplasma

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Neonatal Health

Background:

  • Ureaplasma species are common in the genital tract flora, leading to controversy regarding their pathogenic role.
  • These bacteria are implicated in urogenital infections and are linked to adverse fetal and neonatal outcomes.
  • Rare invasive infections, including meningitis and arthritis, occur in adults and children.

Purpose of the Study:

  • To review the unique microbiological characteristics of Ureaplasma species.
  • To outline the diverse clinical presentations associated with Ureaplasma infections.
  • To discuss current and challenging treatment strategies for Ureaplasma infections, especially in neonates.

Main Methods:

  • Literature review of Ureaplasma microbiology, clinical manifestations, and treatment.
  • Synthesis of data on Ureaplasma's role in urogenital and invasive infections.
  • Analysis of treatment challenges, particularly in the neonatal intensive care setting.

Main Results:

  • Ureaplasma has a demonstrated causal role in specific urogenital infections.
  • Perinatal Ureaplasma infection is associated with significant fetal and neonatal morbidity and mortality.
  • Invasive Ureaplasma infections, though rare, present in various forms across age groups.

Conclusions:

  • Ureaplasma species represent a significant etiological agent in certain human diseases.
  • Effective management of Ureaplasma infections requires understanding its unique biology and clinical spectrum.
  • Neonatal Ureaplasma infections pose particular therapeutic challenges requiring further investigation.
Keywords:
ChildGenitourinaryMacrolideMeningitisMycoplasmaNeonateNewbornPerinatal infectionsPregnancy

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