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The Longitudinal Youth at Risk Study (LYRIKS)--an Asian UHR perspective
Jimmy Lee1, Gurpreet Rekhi, Natasha Mitter
1Research Division, Institute of Mental Health, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, National University of Singapore, Singapore.
Schizophrenia Research
|October 22, 2013
Summary
This study investigated risk factors for psychosis prodrome in Singaporean youth. The Longitudinal Youth at Risk Study (LYRIKS) identified clinical and social characteristics of ultra high risk individuals, with a 3.5% conversion rate to psychosis at 6 months.
Area of Science:
- Psychiatry and Mental Health
- Neuroscience
- Public Health
Background:
- Research on psychosis prodrome risk factors lacks homogeneity, potentially due to population-specific factors.
- Few studies have focused on Asian populations, whose socio-cultural contexts differ from Western ones.
- Singapore presents a unique setting with low substance abuse rates, ideal for studying psychosis prodrome.
Purpose of the Study:
- To assess ultra high risk (UHR) individuals in Singapore.
- To identify clinical, social, neuropsychological, and biological risk factors specific to the local population.
- To detail the methodology and baseline characteristics of the LYRIKS cohort.
Main Methods:
- Longitudinal Youth at Risk Study (LYRIKS) in Singapore, commencing in 2008.
- Recruitment of 173 UHR individuals over 4 years at a single site.
- Assessment of clinical, social, and functioning characteristics at baseline.
Main Results:
- 78% of the UHR sample had a psychiatric disorder, with Major Depressive Disorder in over half.
- Mean Global Assessment of Functioning (GAF) score was 57.4, indicating moderate impairment.
- A 6-month conversion rate to psychosis of 3.5% (n=6) was observed.
Conclusions:
- The LYRIKS study provides valuable baseline data on UHR individuals in a unique Asian context.
- While baseline characteristics were similar to other cohorts, the observed conversion rate warrants further longitudinal investigation.
- Ongoing follow-up will assess psychosis incidence and the impact of various factors on outcomes.
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