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Acute generalized exanthematous pustulosis due to dextromethorphan
M M Otero Rivas1, P Sánchez Sambucety, J M García-Ruiz de Morales
1Complejo Asistencial Universitario de Leon. Motero@aedv.es.
Dermatology Online Journal
|October 22, 2013
Summary
Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction. This case highlights dextromethorphan in antitussives as a potential trigger for AGEP.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a severe, rare cutaneous drug reaction.
- It is characterized by widespread erythema and non-follicular pustules.
Observation:
- A patient presented with AGEP following the ingestion of three distinct antitussive medications.
- Dextromethorphan was identified as the sole common ingredient across all three agents.
Findings:
- The case suggests a potential causal link between dextromethorphan exposure and the development of AGEP.
- This highlights the importance of considering antitussive agents in AGEP differential diagnosis.
Implications:
- Clinicians should be aware of dextromethorphan as a potential AGEP trigger.
- Further research is warranted to confirm dextromethorphan's role in AGEP pathogenesis.
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