Related Experiment Video

Updated: May 6, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
08:22

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

Published on: July 21, 2013

14.6K

Brain infarction with a predilection for cerebellum in a patient with double-outlet left ventricle and vascular

Yasuteru Inoue1, Masaki Watanabe1, Yukio Ando1

  • 1Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 22, 2013
PubMed

Insights

Double-outlet left ventricle (DOLV), a rare heart defect, can cause cerebellar strokes due to unique blood flow patterns. This case highlights the link between DOLV anatomy and specific brain infarction locations.

Area of Science:

  • Cardiology
  • Neurology
  • Pediatric Cardiology

Background:

  • Double-outlet left ventricle (DOLV) is a rare congenital heart defect where both great arteries arise from the left ventricle.
  • Patients with DOLV may present with complex cardiovascular anomalies and associated risks.

Observation:

  • A case of DOLV with co-existing vascular malformations presented with brain infarction.
  • The ischemic lesions showed a predilection for the cerebellum.

Findings:

  • The specific anatomy of the brachiocephalic trunk in DOLV patients may lead to altered hemodynamics.
  • Significantly higher mean flow velocity in vertebral arteries compared to common carotid arteries was observed, suggesting a mechanism for cerebellar hypoperfusion.

Implications:

  • This case suggests a potential link between DOLV-associated hemodynamic changes and the pattern of ischemic brain injury.
  • Understanding these mechanisms is crucial for managing neurological complications in patients with congenital heart disease.

Keywords:
Ischemic strokedeep vein thrombosisdouble-outlet left ventricledural arteriovenous fistula

More Related Videos

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment18:50

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment

Published on: September 25, 2009

13.2K
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.0K

Related Concept Videos

The Arch of Aorta01:10

The Arch of Aorta

The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
2.2K
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
31
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
57
Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
5.4K
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
74
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
57