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Soluble B7-H3 elevations in hospitalized children with Mycoplasma pneumoniae pneumonia

Zheng-Rong Chen1, Guang-Bo Zhang, Yu-Qing Wang

  • 1Department of Respiratory Disease, Children's Hospital Affiliated to Soochow University, Suzhou 215003, China.

Diagnostic Microbiology and Infectious Disease
|October 22, 2013
PubMed

Insights

Soluble B7-H3 (sB7-H3) levels are elevated in children with Mycoplasma pneumoniae pneumonia and correlate with disease severity. sB7-H3 may play a role in the immune response to this infection.

Area of Science:

  • Immunology
  • Pediatric Infectious Diseases

Background:

  • Mycoplasma pneumoniae pneumonia is a common respiratory infection in children.
  • The role of soluble B7-H3 (sB7-H3) in the immunopathogenesis of M. pneumoniae pneumonia is not well understood.

Purpose of the Study:

  • To investigate the associations between sB7-H3 levels and cytokines, clinical characteristics, and laboratory findings in children with M. pneumoniae pneumonia.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure sB7-H3 and cytokine levels (TNF-α, IFN-γ, IL-4, IL-10).
  • Clinical data including symptom duration, neutrophil percentage, and C-reactive protein levels were collected.
  • Thirty-two children diagnosed with M. pneumoniae pneumonia were enrolled.

Main Results:

  • sB7-H3 levels were significantly higher in patients with M. pneumoniae pneumonia compared to controls.
  • sB7-H3 levels correlated positively with TNF-α, symptom duration, neutrophil percentage, and C-reactive protein.
  • sB7-H3 levels decreased after treatment.

Conclusions:

  • sB7-H3 may be involved in the immune response during M. pneumoniae pneumonia.
  • Elevated sB7-H3 is associated with increased TNF-α and neutrophil activation.
  • sB7-H3 could serve as a potential biomarker for M. pneumoniae pneumonia severity.

Keywords:
Community-acquired pneumoniaMycoplasma pneumoniaSoluble B7-H3

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