Photodynamic therapy for polypoidal choroidal vasculopathy.
Patrycja Nowak-Sliwinska1, Hubert van den Bergh, Michel Sickenberg
1Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland; University Hospital (CHUV), Lausanne, Switzerland.
Progress in Retinal and Eye Research
|October 22, 2013
Summary
Photodynamic therapy (PDT) is effective for polypoidal choroidal vasculopathy (PCV), a condition often seen in pigmented individuals. Combination therapies involving PDT show promising results for treating PCV.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vascular Biology
Background:
- Exudative age-related macular degeneration (AMD) was initially treated with Photodynamic Therapy (PDT).
- Distinguishing Polypoidal Choroidal Vasculopathy (PCV) from choroidal neovessels (CNV) in AMD using fluorescein angiography (FA) can be challenging.
- Indocyanine Green angiography improved PCV diagnosis, particularly in pigmented populations.
Purpose of the Study:
- To review data on Photodynamic Therapy (PDT) for Polypoidal Choroidal Vasculopathy (PCV).
- To evaluate combination therapies and alternative treatments for PCV.
- To compare similarities and differences between AMD and PCV.
Main Methods:
- Review of existing data on PDT for PCV.
- Analysis of combination therapies including anti-VEGF agents and steroids.
- Comparison of PDT efficacy with anti-VEGF monotherapy for PCV.
Main Results:
- PDT is a promising treatment for PCV, with a low retreatment rate.
- Anti-VEGF monotherapy was less successful for PCV compared to wet AMD.
- Combination therapy of PDT with anti-VEGF agents and steroids showed significant efficacy.
Conclusions:
- PDT is an effective therapy for PCV, especially in pigmented individuals.
- Combination therapies enhance treatment outcomes for PCV.
- Further research into AMD and PCV similarities and differences is warranted.
Keywords:
11-cis-RAL11-cis-REH11-cis-retinal11-cis-retinyl ester hydrolaseA2EA2PEABCA4AMDAREDSATP-binding cassette transporter 4Age-related macular degenerationAnti-AngiogenesisBCVABPDMABVNCFHCNVCRALBPChoroidal neovascularizationELNETDRSEarly Treatment Diabetic Retinopathy StudyFVHTRA1ICGAIVBIVTALRATMIIN-ret-PEN-retinylidine-phosphatidyl ethanolamineOCTOSOptical coherence tomographyPCVPDGFPEPEDPEGFPTPCPolypoidal choroidal vasculopathyRDHROSRPEDSMASNPV(®)-PDTVDAVEGF-AVisudyne(®)-photodynamic therapyage-related eye disease studyage-related macular degenerationall-trans-RALall-trans-REall-trans-retinalall-trans-retinal esterbenzoporphyrin derivative monoacid ring Abest-corrected visual acuitybranching vascular networkcellular retinaldehyde-binding proteinchoroidal neovascularizationcomplement factor Hdi-retinoid-pyridinium-ethanolamineelastin geneepithelium-derived growth factorfeeder vesselshigh temperature required factor A1indocyanine green angiographyintravitreal ranibizumabintravitreal triamcinolone acetonidelecithin:retinol acyltransferasemTORmammalian target of rapamycinmetarhodopsin IIoptical coherence tomographyouter segmentpermeability transition pore complexphosphatidylethanolaminephosphatidylpyridinium-bisretinoidpigment epithelial detachmentplatelet-derived growth factorpolypoidal choroidal vasculopathyreactive oxygen speciesretinal pigmented epithelium detachmentretinol dehydrogenase enzymessingle nucleotide polymorphismsmooth muscle actinvWfvascular disrupting agentvascular endothelial growth factor Avon Willebrand factorMore Related Videos
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