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Abnormal cortical thickness in heroin-dependent individuals.

Meng Li1, Junzhang Tian2, Ruibin Zhang1

  • 1Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, PR China.

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Heroin dependence alters brain cortical thickness, particularly in frontal and temporal regions. Longer heroin use duration correlates with greater brain changes in heroin-dependent individuals.

Keywords:
AddictionCortical thicknessDuration of heroin useROI-wiseVertex-wise

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Area of Science:

  • Neuroimaging
  • Addiction Neuroscience
  • Brain Morphology

Background:

  • Previous studies link heroin dependence to gray matter changes.
  • The impact of heroin on cortical thickness remains under-investigated.

Purpose of the Study:

  • To investigate cortical thickness differences in heroin-dependent individuals (HDIs) compared to healthy controls (HCs).
  • To explore the relationship between cortical thickness and heroin use duration.

Main Methods:

  • Acquired 3D high-resolution structural MRI data from 18 HDIs and 15 HCs.
  • Utilized FreeSurfer software for vertex-wise and ROI-wise cortical thickness analysis.

Main Results:

  • HDIs exhibited significantly decreased cortical thickness in regions like the superior frontal and insula.
  • Increased cortical thickness was observed in areas including the superior parietal and lingual regions in HDIs.
  • Cortical thickness in the right superior frontal and insula negatively correlated with heroin use duration.

Conclusions:

  • Heroin dependence is associated with widespread cortical thickness abnormalities.
  • Duration of heroin use is a significant factor contributing to these brain alterations.