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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
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Fibroblastic rheumatism - case report.

Rita Cabral, A Brinca, J C Cardoso

    Acta Reumatologica Portuguesa
    |October 22, 2013
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    Summary
    This summary is machine-generated.

    Fibroblastic rheumatism is a rare condition causing inflammatory polyarthritis and skin nodules. Early diagnosis through clinical and histopathological correlation led to successful treatment in a presented case.

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    Area of Science:

    • Rheumatology
    • Dermatology
    • Pathology

    Background:

    • Fibroblastic rheumatism is a rare fibro-proliferative disease of unknown cause.
    • It presents with sudden onset inflammatory polyarthritis and/or cutaneous nodules.

    Observation:

    • A case of a patient with multiple cutaneous nodules on the hands is described.
    • The patient had no articular or systemic complaints.

    Findings:

    • Clinical and histopathological correlation confirmed the diagnosis of fibroblastic rheumatism.
    • The patient experienced a favorable outcome following diagnosis and treatment.

    Implications:

    • This case highlights the importance of considering fibroblastic rheumatism in patients with cutaneous nodules.
    • Accurate diagnosis and prompt treatment are crucial for favorable outcomes in rare fibro-proliferative diseases.