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Updated: May 6, 2026
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of
Raimundo Nonato Campos-Sousa1, Elizabeth Maria Aparecida Barasnevicius Quagliato, Kelson James Almeida
1Movement Disorders Unit, Department of Neurology, Universidade Federal do Piauí, TeresinaPI, Brazil.
Introduction:
Detrusor hyperactivity is the leading cause of urinary dysfunction in Parkinson's disease (PD). There are few studies correlating PD clinical aspects with this autonomic feature.
Methods:
A cohort of 63 women with PD were prospectively examined for assessment of clinical aspects and disease severity using unified Parkinson's disease rating scale and Hoehn-Yahr scale, respectively. The urologic function was evaluated by the urodynamic study. Two groups were categorized at this time - groups with and without detrusor hyperactivity. After seven years, the same parameters were re-evaluated.
Results:
Progression of the disease on mental scores was found in the group with detrusor hyperactivity. On follow-up, clinical symptoms and severity did not show significant worsening between the groups.
Conclusion:
Detrusor hyperactivity is a frequent urodynamic finding in PD, and even though it is associated with dopaminergic dysfunction, it cannot be blamed as a factor of worsening motor performance, but is probably associated with poor cognitive and mental prognosis.
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