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A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
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Published on: October 14, 2016

[An unusual case of a basophilic variant of chronic myelogenous leukemia]

D Bondare, D Grasmane, I Baravika

    Folia Haematologica (Leipzig, Germany : 1928)
    |January 1, 1985
    PubMed

    The described basophilic variant of CML in blastic crisis was characterized by a distinct hyperhistaminemia, a moderate hypocoagulation and an insufficiently effective cytostatic therapy. Cell kinetic was characterized by a marked diminution of the whole marketing index (with H3-thymidine) of blasts and immature basophils with simultaneous prolongation of the generation time in comparison to myeloblasts at the chronic stage of the CML. Aneuploid cell clones prevailed in the bone-marrow.

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