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A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat

Published on: June 29, 2021

A rat model for chronic spinal nerve root compression.

Feng Xue¹, Youzhen Wei, Yongqiang Chen

¹Department of Orthopaedics, Fengxian District Central Hospital, Nanfeng Road 6600, Shanghai, 201499, China.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

|October 22, 2013

Summary

This summary is machine-generated.

This study developed a rat model of chronic spinal nerve root compression to mimic lumbar spinal stenosis and disc herniation. The model showed recoverable nerve root damage and microglial activation, validating its use in studying these conditions.

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Last Updated: May 6, 2026

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat

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Published on: June 29, 2021

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

A Contusion Model of Severe Spinal Cord Injury in Rats

A Contusion Model of Severe Spinal Cord Injury in Rats

Published on: August 17, 2013

Area of Science:

Neuroscience
Pathology
Surgical Models

Background:

Radiculopathy from lumbar spinal stenosis and disc herniation has unclear pathophysiology.
Understanding nerve root damage and spinal cord reactions is crucial.

Purpose of the Study:

To create a chronic spinal nerve root compression model in rats simulating lumbar spinal stenosis/disc herniation.
To investigate pathological changes in the nerve root and microglia response in the spinal cord.

Main Methods:

Utilized silicone tube compression on L5 nerve roots in 30 rats.
Sham group underwent only exposure; model groups were analyzed at 3, 8, 12 days, 45 days, and 5 months.
Examined nerve root structure via electron microscopy and spinal cord microglia via immunohistochemistry.

Main Results:

Compression caused significant myelin sheath damage and axon changes, particularly evident by 12 days.
Microglial activation (Iba1-positive cells) increased in the spinal cord dorsal and ventral horns post-compression.
Nerve root structure and microglia returned to near-normal states by 5 months, indicating recovery.

Conclusions:

Silicone tube compression effectively models recoverable nerve root damage and associated spinal cord microglial response.
This model accurately mimics the pathological changes seen in lumbar spinal stenosis and disc herniation.