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DNA restriction polymorphism of alpha-fetoprotein gene after digestion by MspI endonuclease
Human Heredity
|January 1, 1985
Abstract:
Hybridization of alpha-fetoprotein clones cDNA with human DNAs digested by seven restriction endonucleases reveals one polymorphism. This polymorphism, detected after restriction by MspI, is at low frequency (f = 0.02) and is validated by family analysis. It corresponds to an intronic sequence, for a methylated site external to the probes utilized.