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Adenosine receptor inhibition attenuates the decrease in cutaneous vascular conductance during whole-body cooling

Brendan Swift1, Ryan McGinn, Daniel Gagnon

  • 1G. P. Kenny: University of Ottawa, School of Human Kinetics, 125 University Private, Room 367, Montpetit Hall, Ottawa, Ontario, Canada K1N 6N5. gkenny@uottawa.ca.

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Summary
This summary is machine-generated.

Adenosine receptor blockade attenuated the reduction in skin blood flow during whole-body cooling. This suggests adenosine plays a role in regulating cutaneous vascular conductance during cold exposure.

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Area of Science:

  • Physiology
  • Thermoregulation
  • Vascular Biology

Background:

  • Adenosine exhibits dual effects on blood vessels, but its role in skin blood flow during cooling is unclear.
  • Understanding adenosine's influence on cutaneous vascular conductance (CVC) is crucial for thermoregulation research.

Purpose of the Study:

  • To investigate the effect of adenosine receptor antagonism on reflex cutaneous vasoconstriction during whole-body cooling.
  • To determine adenosine's contribution to the regulation of CVC under thermal stress.

Main Methods:

  • Microdialysis was used to infuse adenosine receptor antagonist (theophylline) and nitric oxide synthase inhibitor (l-NAME) into the forearm skin of subjects.
  • Whole-body cooling and heating were induced using a water-perfusion garment.
  • Cutaneous blood flow was measured using laser-Doppler, and CVC was calculated.

Main Results:

  • Blocking adenosine receptors with theophylline significantly attenuated the decrease in CVC during both cooling phases compared to control.
  • The combination of theophylline and l-NAME also showed higher CVC during cooling compared to l-NAME alone.
  • These results indicate adenosine contributes to the reduction in skin blood flow during cooling.

Conclusions:

  • Non-selective antagonism of adenosine receptors reduces the decrease in cutaneous vascular conductance during whole-body cooling from hyperthermia.
  • Adenosine appears to play a role in mediating reflex cutaneous vasoconstriction in response to cold exposure.
  • Further research can explore targeted adenosine receptor modulation for therapeutic applications in thermoregulation.