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New therapeutic alternatives for the management of dyslipidemia

Manouchkathe Cassagnol1, Danielle Ezzo, Priti N Patel

  • 1St. John's University, College of Pharmacy and Health Sciences, Department of Clinical Pharmacy Practice, Queens, New York, USA and Long Island Jewish Medical Center, Department of Pharmacy, New Hyde Park, New York, USA.

Journal of Pharmacy Practice
|October 22, 2013
PubMed

Insights

New lipid-lowering therapies offer advanced treatment options for hypercholesterolemia, a condition significantly contributing to coronary heart disease (CHD). These novel agents provide unique pharmacological approaches for managing high cholesterol levels in affected adults.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Hypercholesterolemia impacts over 34 million US adults.
  • It is a primary driver of coronary heart disease (CHD).
  • Conventional treatments like statins are effective but novel options are emerging.

Purpose of the Study:

  • To introduce novel lipid-lowering agents.
  • To highlight their unique pharmacological properties.
  • To discuss their role in managing hypercholesterolemia and CHD.

Main Methods:

  • Review of recently FDA-approved lipid-lowering medications.
  • Analysis of their pharmacological mechanisms.
  • Discussion of their clinical application in hypercholesterolemia management.

Main Results:

  • Three novel agents approved: Lomitapide, Mipomersen, and Icosapent.
  • These drugs offer distinct mechanisms for lowering lipids.
  • They represent new therapeutic avenues for patients with hypercholesterolemia.

Conclusions:

  • Novel agents like Lomitapide, Mipomersen, and Icosapent expand treatment options.
  • These therapies provide unique pharmacological approaches.
  • They offer new hope for managing hypercholesterolemia and reducing CHD risk.

Keywords:
ezetimibe/atorvastatinhypercholesterolemiaicosapentlomitapidemipomersen

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