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Evaluation of treatment with hydrocortisone on oxidant/antioxidant system in preterm infants with BPD
1Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. kocabasgonca@mynet.com.
Insights
Hydrocortisone treatment improves the antioxidant system in preterm infants with bronchopulmonary dysplasia (BPD). This therapy reduces oxidative stress, indicated by lower oxidant status and higher antioxidant capacity post-treatment.
Area of Science:
- Neonatal research
- Pediatric pulmonology
- Oxidative stress mechanisms
Background:
- Oxidative stress is implicated in bronchopulmonary dysplasia (BPD) development.
- A strong link exists between oxidative stress and inflammation.
- Hydrocortisone is used in BPD treatment, but its effect on the antioxidant system requires investigation.
Purpose of the Study:
- To investigate the impact of hydrocortisone on the antioxidant system in preterm infants diagnosed with BPD.
- To assess changes in oxidative stress markers following hydrocortisone therapy.
Main Methods:
- Enrolled 33 preterm infants with severe BPD receiving hydrocortisone therapy.
- Measured total oxidant status (TOS), total antioxidant capacity (TAC), and calculated oxidative stress index (OSI) before and after treatment.
- Statistically compared pre- and post-treatment levels of TOS, TAC, and OSI.
Main Results:
- Pre-treatment levels showed high TOS and OSI, with low TAC in infants with BPD.
- Following hydrocortisone treatment, a significant decrease in TOS and OSI was observed.
- A statistically significant increase in TAC levels was noted post-treatment.
Conclusions:
- Hydrocortisone therapy enhances the antioxidant system in preterm infants with BPD.
- Treatment with hydrocortisone effectively reduces oxidative stress in this patient population.
- Further research is needed to fully elucidate the physio-pathogenesis.
Aim:
Evidence that oxidative stress plays a role in the development of bronchopulmonary dysplasia (BPD). There is a close relationship between oxidative stress and inflammation. In this study, it is aimed to investigate influences of hydrocortisone used in the treatment of BPD on anti-oxidant system in preterm infants with BPD.
Patients And Methods:
The study enrolled 33 infants with severe BPD who were undergone inpatient treatment in neonatal intensive care unit (NICU) of our Hospital and received therapy with hydrocortisone. Total oxidant status (TOS) and total anti-oxidant capacity (TAC) levels of infants enrolled to the study before and one week after the hydrocortisone therapy were studies and oxidative stress index levels were calculated. Pre- and post-treatment TOS, TAC and OSI index levels were statistically compared.
Results:
In preterm infants with BPD, who were enrolled into the study, TOS and OSI index were found high, whereas TAC values were low. Following the treatment with hydrocortisone, statistically significant decrease in TOS and OSI index and statistically significant elevation in TAC levels were found in comparison with pre-treatment levels.
Conclusions:
The treatment with hydrocortisone, which is used for BPD, improves anti-oxidant system and reduces oxidative stress in infants with BPD. There is need for further studies in order to clarify the physio-pathogenesis.
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