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Updated: May 6, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
Iodinated contrast media can induce long-lasting oxidative stress in hemodialysis patients
Seun Deuk Hwang1, Yoon Ji Kim, Sang Heun Lee
1Division of Nephrology, Department of Internal Medicine, Kwandong University Medical College, 24 Beomil-ro 579beon-gil, Gangneung 210-701, Korea. diva502@kd.ac.kr.
Purpose:
Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population.
Materials And Methods:
We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days.
Results:
In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure.
Conclusion:
Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.
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